Peer-reviewed veterinary case report
CCNU chemotherapy for dogs with epitheliotropic lymphoma response
By Williams, Laurel E et al.·Published in Journal of veterinary internal medicine·2006·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: CCNU in the treatment of canine epitheliotropic lymphoma.
- Species:
- dog
Plain-English summary
A group of 36 dogs with epitheliotropic lymphoma, a type of skin cancer, were treated with a chemotherapy drug called CCNU. Most of these dogs had the skin form of the disease, while a few had the oral form. After starting treatment, 28 dogs showed a positive response, with some experiencing complete or partial remission for several months. However, some dogs faced side effects, including low blood cell counts and gastrointestinal issues. Overall, CCNU proved to be an effective treatment option for these dogs with lymphoma.
People also search for: dog skin cancer treatment · CCNU chemotherapy for dogs · canine lymphoma symptoms
Abstract
This retrospective study examined the use of CCNU (1-[2-chloroethyl]3-cyclohexyl-1-nitrosurea) in 36 dogs with epitheliotropic lymphoma. Thirty-one (86%) dogs had the cutaneous form of disease, and 5 (14%) dogs had the oral form of disease. Nineteen (51%) dogs were treated with other chemotherapeutic agents before receiving CCNU. All dogs had detectable disease at the time CCNU therapy was initiated. Dogs received a median starting CCNU dosage of 70 mg/m2 (range, 50-100 mg/m2). The median number of treatments administered was 3 (range, 1-12 treatments). After the initial treatment, the CCNU dosage was adjusted in 9 of 26 (35%) dogs in which CCNU was continued: 7 had dosage reductions, and 2 had dosage escalations. Twenty-eight of 36 (78%) dogs had a measurable response to CCNU for a median duration of 106 days (95% confidence interval [CI], 75-182). Six dogs (17%) had a complete response, including 5 dogs with the cutaneous form and 1 dog with the oral form. Twenty-two dogs (61%) had a partial response, including 20 dogs with the cutaneous form and 2 dogs with the oral form, for a median duration of 88 days (95% CI, 62-170). Toxicoses after CCNU chemotherapy included myelosuppression in up to 29% of the dogs, gastrointestinal signs in up to 22% of the dogs, and liver enzyme activity increases in up to 86% of the dogs. This study demonstrates that CCNU chemotherapy can be considered a reasonable option for the treatment of canine epitheliotropic lymphoma in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16496933/