Peer-reviewed veterinary case report
Dog with heart and nerve lymphoma showing CD3 and CD20 markers
By Nakagun, Shotaro et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: CD3 and CD20 co-expression in a case of canine peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement.
- Species:
- dog
Plain-English summary
An 8-year-old male Pug was brought to the vet because he was not eating, had trouble walking, was vomiting, and was losing weight. The vet found that his heart was enlarged and he had issues with his esophagus and heart function. Sadly, the dog passed away 10 days later, and an autopsy revealed that cancerous cells had invaded his heart and nerves. This case was diagnosed as a type of lymphoma that affected both the heart and nerves, which is quite rare.
People also search for: dog vomiting and weight loss · Pug heart problems · canine lymphoma symptoms · dog not eating and trouble walking
Abstract
An 8-y 9-mo-old male Pug dog was presented because of anorexia, hindlimb ataxia, vomiting, and progressive weight loss. Clinical examinations revealed atrophic hindlimb muscles with decreased postural reaction, enlargement of the cardiac silhouette and megaesophagus on radiograph, and reduced cardiac contractility on ultrasonography. The dog died 10 d after the initial examination, and an autopsy was performed. Grossly, the heart was enlarged, with multifocal-to-coalescing extensive plaque-like areas of discoloration on the epicardial surface. On cross-section, the ventricles were moderately dilated, and discoloration extended into the myocardium. Peripheral lymph nodes were of normal size. Histologically, atypical lymphoid cells replaced the myocardium and also extensively infiltrated peripheral nerve bundles in various organs. With immunohistochemistry, the neoplastic cells exhibited strong immunoreactivity for CD3 and CD20, and were negative for CD8, granzyme B, CD79α, and Pax5. Double-label immunofluorescence confirmed co-expression of CD3 and CD20 by the neoplastic cells. Molecular clonality analysis presented a clonal T-cell receptor gamma gene rearrangement. The case was diagnosed as a CD3+/CD20+ peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement, indicating neurolymphomatosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30129396/