Peer-reviewed veterinary case report
Dog with itchy skin lymphoma showing unusual CD3 and CD20 markers
By Brachelente, C et al.·Published in Veterinary pathology·2016·Department of Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: CD3 and CD20 Coexpression in a Case of Canine Cutaneous Epitheliotropic T-Cell Lymphoma (Mycosis Fungoides).
- Species:
- dog
Plain-English summary
A 14-year-old female spayed Dachshund was brought to the vet because she had severe skin issues, including scaling, redness, itching, a poor coat, and was losing weight. The vet suspected a type of skin cancer called cutaneous epitheliotropic T-cell lymphoma (CETCL) and confirmed it through skin biopsies. Further tests showed unusual cell markers, indicating a specific type of CETCL that had not been previously reported in dogs. Unfortunately, the abstract does not provide information on treatment or outcome, so it's unclear how the dog responded to any therapies.
People also search for: Dachshund skin problems · dog weight loss and itching · cutaneous epitheliotropic T-cell lymphoma in dogs
Abstract
A 14-year-old female spayed Dachshund was presented with generalized scaling, erythema, pruritus, poor quality of hair coat, and progressive weight loss. Cutaneous epitheliotropic T-cell lymphoma (CETCL) was suspected. Skin biopsies were suggestive of CETCL. However, immunohistochemistry revealed the presence of numerous CD20+ and CD3+ cells. Clonality assay demonstrated a clonal T-cell receptor gamma rearrangement and a polyclonal IgH gene rearrangement. Double-label immunofluorescence confirmed coexpression of CD3 and CD20 by neoplastic cells. By double immunohistochemistry, neoplastic cells were CD3+ and PAX5-. The results are compatible with a CD3+, CD20+ CETCL. Coexpression of CD20 and CD3 has been recognized in peripheral T-cell lymphomas. Although documented in human CETCL, it has not been reported in canine CETCL. The pathogenetic basis of CD20 expression in mycosis fungoides is explored.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26354309/