Peer-reviewed veterinary case report
CD3-CD20-positive nodal lymphoma with cross-lineage rearrangement in a dog.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2020
- Authors:
- Nicoletti, Arturo et al.
- Affiliation:
- School of Agriculture and Veterinary Medicine · Italy
- Species:
- dog
Abstract
A 7-y-old mixed-breed male dog was presented with a history of generalized lymphadenopathy. Fine-needle aspirates of the enlarged peripheral lymph nodes were suggestive of lymphoma. Histologic examination of a retromandibular lymph node was suggestive of high-grade, medium large-cell lymphoma. Immunohistochemistry revealed concurrent expression of CD3 and CD20. The co-localization of the 2 antigens was confirmed by immunofluorescence. PCR for antigen receptor gene rearrangements (PARR) detected clonal rearrangements for both T-cell receptor gamma and B-cell receptor. The final diagnosis was CD3-CD20-positive anaplastic lymphoma with cross-lineage rearrangement.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33000710/