Peer-reviewed veterinary case report
Dog with lymphoma showing unusual immune cell markers and gene changes
By Nicoletti, Arturo et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2020·School of Agriculture and Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: CD3-CD20-positive nodal lymphoma with cross-lineage rearrangement in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old male mixed-breed dog was brought to the vet because his lymph nodes were swollen all over his body. Tests showed he likely had lymphoma, a type of cancer affecting the lymphatic system. Further examination revealed a specific type of lymphoma that involved both T-cells and B-cells, which is unusual. This diagnosis can be complex, but it helps guide treatment options. The dog may need chemotherapy or other therapies to manage the cancer and improve his health.
People also search for: dog swollen lymph nodes · lymphoma treatment for dogs · mixed-breed dog cancer symptoms
Abstract
A 7-y-old mixed-breed male dog was presented with a history of generalized lymphadenopathy. Fine-needle aspirates of the enlarged peripheral lymph nodes were suggestive of lymphoma. Histologic examination of a retromandibular lymph node was suggestive of high-grade, medium large-cell lymphoma. Immunohistochemistry revealed concurrent expression of CD3 and CD20. The co-localization of the 2 antigens was confirmed by immunofluorescence. PCR for antigen receptor gene rearrangements (PARR) detected clonal rearrangements for both T-cell receptor gamma and B-cell receptor. The final diagnosis was CD3-CD20-positive anaplastic lymphoma with cross-lineage rearrangement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33000710/