Peer-reviewed veterinary case report
CD30 and other markers linked to prognosis in dog skin mast cell
By Ramos, Fernanda Ramalho et al.·Published in Veterinary and comparative oncology·2026·Department of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX-5+ Tumour-Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours.
- Species:
- dog
Plain-English summary
A study found that dogs with skin tumors called cutaneous mast cell tumors (MCTs) often had high levels of a protein called CD30 in their cancer cells. In 53 dogs tested, those with strong CD30 expression and certain types of immune cells present had a shorter survival time after surgery. This suggests that measuring CD30 levels could help veterinarians predict how aggressive the cancer is and guide treatment decisions. More research is needed, but CD30 might be a useful marker for assessing the prognosis in dogs with MCTs.
People also search for: dog skin tumor prognosis · mast cell tumor treatment in dogs · CD30 in canine cancer
Abstract
Canine cutaneous mast cell tumour (MCT) is the most common skin neoplasm in dogs, with histopathology serving as both the diagnostic and primary prognostic tool. However, identifying reliable biomarkers is essential for improving clinical decision-making. CD30, a member of the TNF receptor superfamily, is well-characterised in human haematopoietic malignancies. However, its role in canine MCTs remains unclear. This study aimed to evaluate CD30 expression in neoplastic mast cells and tumour-infiltrating lymphocytes (TILs), and to assess its prognostic significance in canine cutaneous MCTs. Immunohistochemical analysis of CD30, CD3, and PAX-5 was performed on 53 samples, and RNA sequencing was conducted to assess CD30 transcript levels in 17 cases. CD30 was detected in 94.6% of neoplastic mast cells, with strong staining observed in 35 cases and weak staining in 18. Strong CD30 expression (p = 0.0051), CD30+ TIL counts (p = 0.0105) and the diffuse infiltrate distribution pattern of CD3+ TILs (p = 0.0497) were associated with shorter post-surgical survival. RNA sequencing confirmed higher CD30 (TNFRSF8) gene expression levels in high-risk tumours (logFC = 2.3182; FDR = 0.0405). These findings suggest that CD30 is a promising biomarker with potential prognostic value in canine cutaneous MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41741970/