Peer-reviewed veterinary case report
Dog with sudden blindness diagnosed with skin-related brain lymphoma
By Czasch, S et al.·Published in Journal of comparative pathology·2000·Institut fü, Germany·View original on PubMed →
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Original publication title: Central nervous system metastasis of a cutaneous epitheliotropic lymphosarcoma in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old mixed breed German shepherd was brought in after suddenly going blind and showing signs of fever and red patches in the mouth. A biopsy revealed that the dog had a type of skin cancer called cutaneous epitheliotropic lymphosarcoma, which had spread to the brain. Unfortunately, the dog's condition was severe, and it was humanely euthanized. During the examination after death, doctors found a tumor in the brain affecting the area responsible for vision. This case highlights a rare occurrence of skin cancer spreading to the central nervous system in dogs.
People also search for: dog sudden blindness · German shepherd skin cancer · dog brain tumor symptoms
Abstract
This report describes an uncommon case of a cutaneous epitheliotropic T-cell lymphosarcoma with central nervous system (CNS) manifestations in a 9-year-old mixed breed German shepherd dog. The animal had a history of sudden blindness, pyrexia and multifocal areas of hyperaemia in the oral mucosa. A biopsy from the muco-cutaneous junction of the lips led to the diagnosis of an epitheliotropic lymphosarcoma and the animal was humanely destroyed. At necropsy, hyperaemia in the oral mucosa was no longer detectable. In the brain, a mass effacing the optic chiasm and invading the hypothalamic area was found; histological examination revealed lymphoid tumour cell infiltration. In the epithelium of the oral mucosa, intra-epithelial lymphoid tumour cells, sometimes arranged in small clusters (Pautrier's microabscesses), in combination with a mild inflammation in the superficial dermis were observed. Skin and brain tumour cells expressed CD3 antigen, indicating their T-cell origin. This is, to our knowledge, the first report of a cutaneous epitheliotropic lymphosarcoma with CNS metastasis in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10906257/