Peer-reviewed veterinary case report
C-reactive protein and haptoglobin levels in dogs with lymphatic
By Mischke, R et al.·Published in Veterinary journal (London, England : 1997)·2007·Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Changes in C-reactive protein and haptoglobin in dogs with lymphatic neoplasia.
- Species:
- dog
Plain-English summary
A group of dogs with serious blood cancers, including lymphoma and leukemia, showed high levels of certain proteins in their blood called C-reactive protein (CRP) and haptoglobin. These proteins can indicate inflammation or disease, and the dogs with acute lymphoblastic leukemia had the highest levels of haptoglobin. The findings suggest that if your dog has elevated levels of these proteins, it could be a sign of severe lymphatic cancer, and your veterinarian might consider this in their diagnosis. Early detection and treatment are crucial for better outcomes in these cases.
People also search for: dog lymphoma symptoms · elevated CRP in dogs · dog leukemia treatment
Abstract
Acute phase proteins (APP) are regarded as a useful diagnostic tool in humans with lymphomas, leukaemias and multiple myeloma. C-reactive protein (CRP) and haptoglobin concentrations were measured in dogs with malignant multicentric (high grade) lymphoma (n=16), acute lymphoblastic leukaemia (ALL) (n=11), chronic lymphocytic leukaemia (CLL) (n=7) and multiple myeloma (n=8). Twenty-five healthy dogs served as controls. Measurements of the CRP plasma concentration were performed using a commercial ELISA and haptoglobin was measured with an assay based on its haemoglobin binding capacity. Global group comparisons using Kruskal-Wallis-test revealed significant group differences for both APPs (P<0.0001). Median CRP concentrations were increased in all groups with neoplastic lymphatic disorders (lymphoma: 37.2mg/L, ALL: 47.8mg/L, CLL: 35.5mg/L, myeloma: 17.6mg/L) compared to controls (1.67mg/L; P<0.001). Compared to the healthy controls (median=0.59g/L), haptoglobin was especially increased in dogs with ALL (6.8g/L, P<0.0001) followed by dogs with malignant lymphoma (3.8g/L, P<0.0001), CLL (3.2g/L, P=0.0008), and multiple myeloma (3.0g/L, P=0.0163). For both APPs, a wide range of values was found in all patient groups. The results indicate that particularly severe and acute lymphatic neoplasia, such as high grade lymphoma and ALL, cause significant acute phase reactions in dogs and must be included in the differential diagnoses of increased blood levels of these APPs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16901733/