Peer-reviewed veterinary case report
Oxidative stress markers improve after treatment for canine
By Rubio, Camila Peres et al.·Published in Comparative immunology, microbiology and infectious diseases·2016·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs.
- Species:
- dog
Plain-English summary
A group of 12 sick dogs with canine leishmaniosis (a disease caused by a parasite) were treated with standard therapy, and their health was monitored over six months. Before treatment and at 30 and 180 days after, tests showed improvements in certain blood markers related to oxidative stress, which indicates better overall health. Specifically, markers like CUPRAC, thiol, and PON1 increased after treatment, while inflammation markers decreased. This suggests that these tests could help vets track the effectiveness of treatment for canine leishmaniosis.
People also search for: dog leishmaniosis treatment · canine leishmaniosis symptoms · dog oxidative stress markers
Abstract
Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this study we investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infected by CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays total oxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) were included in the panel. In addition, correlations between biomarkers of oxidative stress and inflammation (C-reactive protein (CRP) and ferritin) and urinary protein:creatinine ratio (UPC) were calculated. Serum CUPRAC, thiol and PON1 significantly increased after treatment and were negatively correlated with CRP, ferritin and UPC. This study demonstrates that biomarkers of oxidative stress, not previously studied in leishmaniosis such as CUPRAC and thiol, can change after a successful treatment for CanL showing a potential for use in monitoring the treatment of this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27865264/