Peer-reviewed veterinary case report
Tumor oxygen levels rise during heat and radiation therapy in dog
By Thrall, D E et al.·Published in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2006·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas.
- Species:
- dog
Plain-English summary
A group of dogs with soft tissue sarcomas (a type of cancer) underwent a combination of radiation therapy and hyperthermia (heat treatment) to improve their tumor oxygen levels. The treatment showed that tumors with low oxygen levels before starting therapy experienced an increase in oxygenation that continued throughout the treatment process. This improvement in oxygen levels could help make the radiation therapy more effective at killing cancer cells. However, some tumors showed less favorable changes in oxygenation, which may need more research to understand.
People also search for: dog soft tissue sarcoma treatment · radiation therapy for dog cancer · hyperthermia for dogs with tumors
Abstract
Tumour oxygenation was measured in seven canine soft tissue sarcomas being treated with a fractionated course of radiation and hyperthermia. Measurements obtained during treatment were compared to pre-treatment measurements. The most important finding was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment. This is an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. In other tumours, potentially less advantageous changes in oxygenation may be hyperthermia fractionation related and this deserves further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16891239/