Peer-reviewed veterinary case report
Lipid changes in dogs with parvovirus infection
By Yilmaz, Z & Senturk, S·Published in The Journal of small animal practice·2007·Department of Internal Medicine·View original on PubMed →
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Original publication title: Characterisation of lipid profiles in dogs with parvoviral enteritis.
- Species:
- dog
Plain-English summary
A group of dogs with severe parvoviral enteritis (a serious viral infection) showed symptoms like rapid heart rate, difficulty breathing, low blood pressure, and low white blood cell counts. Blood tests revealed that these dogs had lower levels of total cholesterol and good cholesterol (HDL), while their triglyceride levels were higher compared to healthy dogs. The study found that dogs that did not survive had even lower cholesterol levels than those that did recover. Monitoring these cholesterol levels could help vets assess the severity of the illness and guide treatment decisions.
People also search for: dog parvovirus symptoms · dog low cholesterol treatment · parvoviral enteritis recovery in dogs
Abstract
OBJECTIVE: To characterise the lipid profiles in dogs with parvoviral enteritis. METHODS: Blood was collected before treatment from 30 dogs that fulfilled the criteria for severe sepsis including hypo- or hyperthermia, hypotension, leucopenia, thrombocytopenia and evidences of organ dysfunction. Canine parvovirus was detected by haemagglutination and indirect fluorescence antibody tests in the faeces. Twenty control dogs were also enrolled on the basis of normal physical examination results, complete blood count and serum biochemistry profiles. RESULTS: Tachycardia, tachypnoea, hypotension, leucopenia, thrombocytopenia and increased serum markers of tissue injury (alanine aminotransferase, creatinine kinase myocardial isoenzyme [CK-MB], blood urea nitrogen and creatinine) were observed in dogs with parvoviral enteritis. Serum total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were lower, but serum triglyceride level was higher in dogs with parvoviral enteritis than those in control dogs (P<0.001). Circulating tumour necrosis factor alpha correlated negatively with total cholesterol (r=-0.979; P<0.001) but positively with triglyceride (r=0.953; P<0.001) in dogs with parvoviral enteritis. Serum total cholesterol and high-density lipoprotein cholesterol levels were lower in non-survival (n=9) dogs than in survival dogs (n=21, P<0.001). CLINICAL SIGNIFICANCE: Serum total cholesterol and high-density lipoprotein cholesterol levels decreased, but serum triglyceride level increased in dogs with parvoviral enteritis. Low serum total cholesterol and high-density lipoprotein cholesterol levels may be used as an index of the severity of parvoviral enteritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17617157/