Peer-reviewed veterinary case report
Extracellular protein kinase in dog blood signals cancer presence
By Bhang, D H et al.·Published in Veterinary and comparative oncology·2017·Department of Molecular and Cellular Biology, South Korea·View original on PubMed →
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Original publication title: Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs.
- Species:
- dog
Plain-English summary
Researchers found that a specific protein level in the blood, called ECPKA, can help identify cancer in dogs. They tested blood samples from dogs with different health conditions, including cancer, benign tumors, and healthy dogs. The results showed that dogs with cancer had significantly higher levels of ECPKA compared to those with benign tumors or other health issues. This suggests that measuring ECPKA could be a useful tool for veterinarians to diagnose cancer early in dogs, potentially improving treatment outcomes.
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Abstract
OBJECTIVE: Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP-dependent protein kinase A (ECPKA) level in serum as a useful cancer biomarker in dogs. METHODS: ECPKA levels were detected in sera from dogs with cancers (n = 48), benign tumours (n = 18), and non-tumour diseases (n = 102) as well as healthy control dogs (n = 54) utilizing enzyme-linked immunosorbent assay (ELISA). RESULTS: Sera from dogs bearing various types of cancer exhibited markedly increased levels of ECPKA by up to 7.1-, 8.8-, and 10.9-fold compared with those from dogs harbouring benign tumours, dogs with non-tumour diseases, and healthy control dogs, respectively (P < .0001). In addition, serum ECPKA level did not show statistically significant correlation with gender, breed, or age of dogs or their non-cancerous disease conditions. CONCLUSION: Our data strongly propose that detection of serum ECPKA level is a potential and specific diagnostic tool for cancer in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28185388/