Peer-reviewed veterinary case report
Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr(fa)) rat.
- Journal:
- Biochemical and biophysical research communications
- Year:
- 2008
- Authors:
- Akimoto, Toshio et al.
- Affiliation:
- Nippon Medical School · Japan
- Species:
- rodent
Abstract
The WBN/Kob-Lepr(fa) rat is a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Lepr(fa) rats provide a model of non-insulin-dependent diabetes with obesity. Here, we describe the characteristics of this new animal model in detail. At 7 weeks of age, both male and female obese WBN/Kob rats showed inflammatory cell infiltration of the pancreas that suggested pan-pancreatitis and an abnormal OGTT. At 3 months of age, both male and female obese WBN/Kob rats developed overt diabetes mellitus associated with severe chronic pancreatitis. In contrast, lean female WBN/Kob rats do not develop pancreatitis or diabetes. In WBN/Kob rats, this mutation might promote the onset of severe pancreatitis, leading to the rapid development of diabetes mellitus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18068663/