Peer-reviewed veterinary case report
Plasma profiles of glucose, insulin and lipids in the male WBN/Kob-Lepr(fa) rat, a new model of type 2 diabetes with obesity.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2012
- Authors:
- Kaji, Noriyuki et al.
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- rodent
Abstract
Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr(fa) (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22571894/