Peer-reviewed veterinary case report
Differences in gut bacteria and inflammation in dogs with chronic gut
By Kaga, Chiaki et al.·Published in Scientific reports·2024·Yakult Central Institute, Japan·View original on PubMed →
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Original publication title: Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with chronic enteropathy (CE) or small-cell lymphoma (SCL) showed significant differences in their gut bacteria and inflammatory markers compared to healthy dogs. The study found that dogs with these conditions had lower levels of certain beneficial bacteria and higher levels of harmful bacteria. They also had issues with succinic acid metabolism, which could be linked to their symptoms. While these findings could help in creating new treatments based on gut health, more research is needed to confirm the results.
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Abstract
Dogs diagnosed with chronic enteropathy (CE) or small-cell lymphoma (SCL) exhibit marked differences in faecal microbiota and organic acid profiles compared with healthy dogs, as well as immune abnormalities in intestinal mucosal tissue. However, few studies have analysed trace organic acids, such as succinic acid, which have been suggested to be associated with IBD in humans. Therefore, in this study, we compared the faecal microbiota and organic acid profiles as well as serum inflammatory markers between dogs with disease (n = 11; 6 with CE and 5 with SCL) and healthy controls (n = 16). We also performed machine learning and correlation analysis to obtain more detailed insights into the characteristics of affected dogs. These results revealed that dogs with CE and SCL had lower levels of Erysipelotrichaceae (e.g. Turicibacter and Allobaculum), exhibited abnormalities in the succinic acid metabolism (i.e. succinic acid accumulation and decreased levels of Phascolarctobacterium as succinic acid-utilising bacteria) and increased levels of pathobiont bacteria such as Escherichia-Shigella. Additionally, the presence of Dubosiella was significantly negatively correlated with Canine Inflammatory Bowel Disease Activity Index scores. These findings are expected to aid the development of microbiome-based medications and/or supplements, although further verification is needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39169196/