Peer-reviewed veterinary case report
Protein in urine in Dogue de Bordeaux dogs with kidney disease risk
By Lavoué, Rachel et al.·Published in PloS one·2015·Internal Medicine Unit, France·View original on PubMed →
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Original publication title: Characterization of Proteinuria in Dogue de Bordeaux Dogs, a Breed Predisposed to a Familial Glomerulonephropathy: A Retrospective Study.
- Species:
- dog
Plain-English summary
A group of Dogue de Bordeaux dogs was found to have a high rate of protein in their urine, which can indicate kidney problems. In this study, 102 adult dogs were tested, and about one-third showed abnormal levels of proteinuria, with some having a specific kidney disease called familial glomerulonephropathy. Tests revealed that most dogs with proteinuria had signs of kidney damage. The researchers suggest that a special test could help identify dogs at risk for kidney issues, but more research is needed to understand the connection to the inherited disease.
People also search for: Dogue de Bordeaux protein in urine · dog kidney disease symptoms · how to treat proteinuria in dogs
Abstract
Dogue de Bordeaux dog has been reported to be predisposed to a familial glomerulonephropathy that displays some morphological modifications reported in focal and segmental glomerulosclerosis. Prevalence of quantitatively abnormal renal proteinuria was recently reported to be 33% in this breed. The nature of the proteinuria was assessed by sodium dodecyl sulfate-agarose gel electrophoresis and determinations of urinary markers (urinary retinol-binding protein, urinary N-acetyl-β-glucosaminidase, urinary albumin and urinary immunoglobulin G) on stored specimens. Diagnostic performances of sodium dodecyl sulfate-agarose gel electrophoresis to identify dogs with elevated urinary biomarkers were assessed. Samples from 102 adult Dogue de Bordeaux dogs (47 non-proteinuric [urine protein-to-creatinine ratio ≤ 0.2], 20 borderline-proteinuric [0.2< urine protein-to-creatinine ratio ≤ 0.5] and 35 proteinuric dogs [urine protein-to-creatinine ratio >0.5]) were used, of which 2 were suffering from familial glomerulonephropathy. The electrophoretic protein patterns, for all but one proteinuric dog, were indicative of a glomerular origin and, in all dogs, the urinary albumin concentration related to creatinine concentration and the urinary immunoglobulin G concentration related to creatinine concentration were above the upper limit of the reference interval established for the breed. Sensitivity and specificity of sodium dodecyl sulfate-agarose gel electrophoresis identifying dogs with elevated urinary albumin concentration were 94% and 92%, respectively, while diagnostic performance of sodium dodecyl sulfate-agarose gel electrophoresis in detecting dogs with elevated urinary immunoglobulin G concentration yielded sensitivity and specificity of 90% and 74%, respectively. These results suggest that all proteinuric and some borderline-proteinuric Dogue de Bordeaux dogs likely have underlying glomerular lesions and that sodium dodecyl sulfate-agarose gel electrophoresis and urinary markers might be useful to screen dogs with borderline-proteinuria. Additional investigations are warranted to assess if these findings are related to the familial glomerulonephropathy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26181659/