Peer-reviewed veterinary case report
How enalapril and telmisartan affect kidney disease markers in dogs
By Murdoch, Joanna E et al.·Published in Journal of veterinary internal medicine·2024·Department of Small Animal and Surgery, United States·View original on PubMed →
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Original publication title: Characterization of the circulating markers of the renin-angiotensin-aldosterone system in telmisartan- or enalapril-treated dogs with proteinuric chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of dogs with proteinuric chronic kidney disease (pCKD) were treated with either enalapril or telmisartan to see how these medications affected their kidney function and hormone levels. After 30 days, the dogs treated with telmisartan showed a much greater increase in a beneficial hormone called Ang 1-7 compared to those on enalapril. Both medications helped lower another hormone, aldosterone, which is good for managing kidney disease. Overall, telmisartan appeared to have a more positive effect on certain markers related to kidney health in these dogs.
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Abstract
BACKGROUND: Effects of the renin-angiotensin-aldosterone system (RAAS) inhibitors enalapril and telmisartan on circulating RAAS in dogs with proteinuric chronic kidney disease (pCKD) are undescribed. OBJECTIVES: To characterize the RAAS in untreated dogs with pCKD compared to healthy, life-stage- and sex-matched controls, and in dogs with pCKD after 30 days of treatment with enalapril or telmisartan. ANIMALS: Dogs with pCKD (n = 36) and healthy controls (n = 20). METHODS: Retrospective study of banked samples and previously collected data. Day 0 serum equilibrium concentrations of angiotensin I, II, III, IV, 1-5, and 1-7, and aldosterone, and urinary aldosterone-to-creatinine ratio (UACR) from pCKD dogs were compared to values on day 30 of treatment with enalapril (0.5 mg/kg PO q12) or telmisartan (1 mg/kg PO q24h) and to those of healthy dogs. Data were analyzed using linear mixed models. RESULTS: Compared with healthy dogs, pCKD dogs had significantly higher Ang I, III, 1-5, and 1-7 concentrations, and UACR. Relative to pretreatment values, day 30 Ang II concentrations were significantly increased and decreased in telmisartan- and enalapril-treated pCKD dogs, respectively (both P < .001). Mean (95% confidence interval) percentage change from pretreatment value in serum Ang 1-7 concentration was significantly greater in telmisartan- (753% [489%-1134%]) versus enalapril-treated (149% [69%-268%]) dogs (P < .001). Serum aldosterone decreased with treatment (P = .02 for enalapril, P < .001 for telmisartan), with no difference between groups at day 30. CONCLUSIONS AND CLINICAL IMPORTANCE: Circulating RAAS activity is higher in dogs with pCKD. Compared with enalapril, treatment with telmisartan caused significantly greater increases in the presumed beneficial peptide Ang 1-7.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39206534/