Peer-reviewed veterinary case report
Fecal microbiome differences in cats with inflammatory bowel disease
By Marsilio, Sina et al.·Published in Scientific reports·2019·Department of Small Animal Clinical Science, United States·View original on PubMed →
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Original publication title: Characterization of the fecal microbiome in cats with inflammatory bowel disease or alimentary small cell lymphoma.
- Species:
- cat
Plain-English summary
A group of cats with gastrointestinal issues, specifically inflammatory bowel disease (IBD) and small cell lymphoma (SCL), were studied to understand their gut bacteria. The research found that these cats had a less diverse range of gut bacteria compared to healthy cats, with certain types of bacteria being less common and others more prevalent. This imbalance in gut bacteria, known as dysbiosis, is similar to what is seen in humans with IBD. Understanding these changes could help veterinarians develop better treatments for cats suffering from these conditions.
People also search for: cat inflammatory bowel disease symptoms · cat small cell lymphoma treatment · cat gut bacteria health
Abstract
Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Both IBD and SCL in cats share features with chronic enteropathies such as IBD and monomorphic epitheliotropic intestinal T-cell lymphoma in humans. The aim of this study was to characterize the fecal microbiome of 38 healthy cats and 27 cats with CE (13 cats with IBD and 14 cats with SCL). Alpha diversity indices were significantly decreased in cats with CE (OTU p = 0.003, Shannon Index p = 0.008, Phylogenetic Diversity p = 0.019). ANOSIM showed a significant difference in bacterial communities, albeit with a small effect size (P = 0.023, R = 0.073). Univariate analysis and LEfSE showed a lower abundance of facultative anaerobic taxa of the phyla Firmicutes (families Ruminococcaceae and Turicibacteraceae), Actinobacteria (genus Bifidobacterium) and Bacteroidetes (i.a. Bacteroides plebeius) in cats with CE. The facultative anaerobic taxa Enterobacteriaceae and Streptococcaceae were increased in cats with CE. No significant difference between the microbiome of cats with IBD and those with SCL was found. Cats with CE showed patterns of dysbiosis similar to those in found people with IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31844119/