Peer-reviewed veterinary case report
Extraintestinal E. coli causing pneumonia in dogs and cats in South
By Yun, Chi Sun et al.·Published in Scientific reports·2023·Animal Disease Diagnostic Division, South Korea·View original on PubMed →
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Original publication title: Characterization of the pathogenicity of extraintestinal pathogenic Escherichia coli isolates from pneumonia-infected lung samples of dogs and cats in South Korea.
Plain-English summary
A study found that dogs and cats in South Korea with pneumonia had a type of E. coli bacteria called extraintestinal pathogenic E. coli (ExPEC) in their lungs. This bacteria was linked to severe cases of pneumonia and higher death rates. Specific strains of this bacteria, particularly those from phylogroups B1 and B2, were more common and carried virulence factors that made them more dangerous. Understanding these bacteria can help veterinarians better diagnose and treat pneumonia in pets.
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Abstract
This study aimed to investigate the pathogenicity of extraintestinal pathogenic Escherichia coli (ExPEC) isolated from dog and cat lung samples in South Korea. A total of 101 E. coli isolates were analyzed for virulence factors, phylogroups, and O-serogroups, and their correlation with bacterial pneumonia-induced mortality was elucidated. P fimbriae structural subunit (papA), hemolysin D (hlyD), and cytotoxic necrotizing factor 1 (cnf1) were highly prevalent in both species, indicating correlation with bacterial pneumonia. Phylogroups B1 and B2 were the most prevalent phylogroups (36.6% and 32.7%, respectively) and associated with high bacterial pneumonia-induced mortality rates. Isolates from both species belonging to phylogroup B2 showed high frequency of papA, hlyD, and cnf1. O-serogrouping revealed 21 and 15 serogroups in dogs and cats, respectively. In dogs, O88 was the most prevalent serogroup (n = 8), and the frequency of virulence factors was high for O4 and O6. In cats, O4 was the most prevalent serogroup (n = 6), and the frequency of virulence factors was high for O4 and O6. O4 and O6 serogroups were mainly grouped under phylogroup B2 and associated with high bacterial pneumonia-induced mortality. This study characterized the pathogenicity of ExPEC and described the probability of ExPEC pneumonia-induced mortality.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37019949/