Peer-reviewed veterinary case report
Cat with lymphoma developed muscle twitching from chlorambucil
By Benitah, Noémi et al.·Published in Journal of the American Animal Hospital Association·2003·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Chlorambucil-induced myoclonus in a cat with lymphoma.
- Species:
- cat
Plain-English summary
A cat with intestinal lymphoma was treated with chlorambucil, a medication often used for cancer, but developed unusual symptoms like muscle twitching and agitation. This reaction is known as neurotoxicity, which has been seen in humans but was previously unreported in pets. The case highlights that while chlorambucil can be effective for treating lymphoma, it can also cause side effects affecting the nervous system. Pet owners should be aware of these potential reactions when their cat is undergoing treatment for cancer.
People also search for: cat lymphoma treatment side effects · chlorambucil neurotoxicity in cats · cat muscle twitching after cancer medication
Abstract
Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12755202/