Peer-reviewed veterinary case report
Long-term outlook for dogs with mild chronic inflammatory bowel
By Caulfield, Sarah et al.·Published in Journal of veterinary internal medicine·2026·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: Chronic inflammatory enteropathy without moderate to severe hypoalbuminemia: long-term outcome in 60 dogs.
- Species:
- dog
Plain-English summary
A group of 78 dogs with chronic inflammatory enteropathy (CIE), a condition that affects their intestines, were studied to understand their long-term outcomes. The most common treatment that worked well was a special diet, which helped nearly 90% of the dogs improve without any gastrointestinal-related deaths. Other treatments were less effective, with some dogs experiencing more serious issues. Factors like weight loss and certain lab results were linked to a higher risk of complications. Overall, dogs treated with dietary changes had the best chance of recovery and a longer time without serious problems.
People also search for: dog chronic diarrhea treatment · dog food-responsive enteropathy · signs of dog intestinal problems
Abstract
BACKGROUND: Limited information is available on the long-term prognostic outcome of chronic inflammatory enteropathy (CIE) in dogs with serum albumin concentrations ≥20 g/L. HYPOTHESIS/OBJECTIVES: Assess prognostic factors for dogs with CIE without moderate to severe hypoalbuminemia. ANIMALS: Seventy-eight client-owned dogs with CIE. METHODS: Retrospective study of CIE cases with concurrent duodenal and colonic endoscopic biopsy specimens reviewed by a board-certified veterinary pathologist. Outcome data was collected via an electronic questionnaire distributed to referring veterinary practices. Univariable binary logistic regression assessed associations between clinicopathologic variables and gastrointestinal (GI)-related death. RESULTS: Food-responsive enteropathy (FRE, 48.3%) was the most common CIE treatment subtype, followed by immunosuppressive-responsive enteropathy (IRE, 30%) and non-responsive enteropathy (NRE, 21.7%). Food-responsive enteropathy carried the best outcome (0 GI-related deaths; IRE, 4 GI-related deaths; NRE, 9 GI-related deaths), highest remission rate (89.7%; IRE, 44.4%) and longest median follow-up time (1258 days; IRE, 572 days; NRE, 260 days). Age (odds ratio [OR], 1.015; 95% confidence interval [CI], 1-1.030), weight loss (OR, 5.37; 95% CI, 1.301-22.172), hypocobalaminemia (OR, 6.286; 95% CI, 1.45-27.250), alanine aminotransferase activity (OR, 4.317; 95% CI, 1.182-15.760), duodenal histopathological composite score (OR, 1.27; 95% CI, 1.043-1.545), duodenal lacteal dilatation (OR, 6.647; 95% CI, 2.052-20.389), duodenal crypt dilatation (OR, 3.036; 95% CI, 1.185-7.77), and intraepithelial lymphocytes (OR, 2.602; 95% CI, 1.023-6.26) were significantly positively associated with GI-related death, with vomiting being protective (OR, 0.189; 95% CI, 0.05-0.715). CONCLUSIONS AND CLINICAL IMPORTANCE: Histopathologic variables were associated with outcome in non- to mildly hypoalbuminemic dogs with CIE, indicating their potential as prognostic markers, as well as possible roles in guiding treatment and monitoring disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41742531/