Peer-reviewed veterinary case report
Dog with low white blood cells diagnosed with rare leukemia type
By Museux, Kristina et al.·Published in Veterinary clinical pathology·2019·Laboratoire IDEXX, France·View original on PubMed →
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Original publication title: Chronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia.
- Species:
- dog
Plain-English summary
A 10-year-old mixed-breed dog was brought in for low white blood cell counts, specifically neutrophils and lymphocytes, which had been noticed for almost three years without any other symptoms. After tests including a bone marrow examination and ruling out infections, the dog was diagnosed with a rare type of leukemia called subleukemic large granular lymphocytic leukemia. Fortunately, the dog responded well to treatment and continued to live for another 2.5 years before passing away from an unrelated issue.
People also search for: dog low white blood cell count · dog leukemia treatment · symptoms of dog neutropenia
Abstract
T-cell large granular lymphocytic leukemia (T-cell LGLL) is the most common presentation of chronic lymphocytic leukemia (CLL) in dogs. Aleukemic or subleukemic leukemia is a particularly rare variation in both humans and dogs, where bone marrow proliferation is either not or only sparsely translated in the peripheral blood. Neutropenia is a prominent feature in cases of human T-cell LGLL but is normally absent in canine CLL. This report describes a case of a dog presented with an almost 3-year history of asymptomatic neutropenia, lymphopenia, and thrombocytopenia (without anemia). A bone marrow examination, the exclusion of infectious diseases, and clonality testing led to the diagnosis of subleukemic LGLL that responded well to therapy (death occurred 2.5 years later due to an unrelated cause).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31808187/