Peer-reviewed veterinary case report
Chronic Pancreatitis with Acinar-Ductal Metaplasia and Ductal Dysplasia in a Horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2015
- Authors:
- Leipig, M et al.
- Affiliation:
- Institute of Veterinary Pathology · Germany
- Species:
- horse
Plain-English summary
A 16-year-old Friesian gelding was experiencing repeated episodes of colic, which is severe abdominal pain, and was put to sleep during surgery because doctors suspected he had cancer in his abdomen. After he passed away, a thorough examination of his pancreas showed it was abnormally firm and had a lobular structure with several cavities. Further testing revealed he had severe chronic inflammation of the pancreas, along with changes in the cells that could lead to cancer, which likely caused his ongoing colic. These changes in the pancreas are similar to those seen in humans with certain pancreatic conditions. Unfortunately, the treatment options were limited, and the horse was euthanized due to the severity of his condition.
Abstract
A 16-year-old Friesian gelding with relapsing colic was humanely destroyed during diagnostic laparotomy due to suspected abdominal neoplasia. On post-mortem examination, the pancreas appeared as a firm mass (20 × 8 × 8 cm). The cut surface had a lobular structure with multiple cavities. Histological examination revealed severe chronic fibrosing pancreatitis with acinar-ductal metaplasia and duct dysplasia, which was considered to be the cause of the recurrent colic. Formation of tubular complexes within a background of acinar-ductal metaplasia is similar to the regressive lesions detected in the human pancreas in the context of inflammation, duct obstruction, cystic fibrosis and neoplasia. Pancreatic acinar-ductal metaplasia and ductal dysplasia are considered to be preneoplastic conditions in man and in the mouse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26142615/