Peer-reviewed veterinary case report
Bone marrow disorders causing anemia in Miniature Dachshunds
By Tani, Akiyoshi et al.·Published in The Journal of veterinary medical science·2020·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders.
- Species:
- dog
Plain-English summary
A Miniature Dachshund with severe anemia was found to have a bone marrow disorder that was not cancer-related. This breed is particularly prone to conditions like immune-mediated anemia, which can make it hard for the body to produce healthy red blood cells. The study showed that some Miniature Dachshunds respond well to immunosuppressive treatments, while others do not. Those that didn't respond had specific blood features, like high platelet counts and abnormal blood cell shapes, which could help predict treatment outcomes. Further research is needed to understand these disorders better.
People also search for: Miniature Dachshund anemia treatment · dog bone marrow disorder symptoms · why is my dog tired and weak
Abstract
Non-neoplastic bone marrow disorders such as non-regenerative immune-mediated anemia, pure red cell aplasia, and myelodysplastic syndrome are major causes of non-regenerative anemia in dogs. However, there has been no study on the clinical and clinicopathological features of canine non-neoplastic bone marrow disorders in Japan. Hence, we first investigated the breed disposition of non-neoplastic bone marrow disorders that induce anemia as a retrospective study and found that Miniature Dachshund (MD) was a predisposed breed. Based on this finding, we investigated the clinical and clinicopathological features of non-neoplastic bone marrow disorders in MDs as a preliminary retrospective study, and we compared them between immunosuppressive treatment-responsive and -resistant MDs. We found that treatment-resistant MDs showed thrombocytosis and increased frequencies of dysplastic features in the peripheral blood. These results indicate that bone marrow disorders in treatment-resistant MDs might manifest distinct features compared with those in treatment-sensitive MDs, and sensitivity to immunosuppressive treatments could be predicted based on thrombocytosis and dysplastic features in the peripheral blood. Further studies that examine aberrations in the genome are needed to elucidate the pathophysiology of bone marrow disorders in MDs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32307340/