Peer-reviewed veterinary case report
Feline intraocular lymphoma types and outcomes in cats
By Musciano, Ayla R et al.·Published in Veterinary ophthalmology·2020·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Clinical and histopathological classification of feline intraocular lymphoma.
- Species:
- cat
Plain-English summary
A group of cats diagnosed with intraocular lymphoma, a type of eye cancer, was studied to understand their symptoms and outcomes. Many of these cats also had eye inflammation (uveitis) and increased eye pressure (glaucoma). The most common type of lymphoma found was diffuse large B-cell lymphoma. Cats with a solitary form of the disease had a better survival rate, living an average of 154 days, compared to 69 days for those with more widespread disease. This suggests that early detection and treatment of solitary intraocular lymphoma can lead to better outcomes.
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Abstract
This retrospective study aimed to describe and classify cats with intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared with ocular manifestations of multicentric disease and assess the clinical outcomes of these patients. One hundred seventy-two cases identified through biopsy submissions were reviewed histologically; 163 of these cases were subtyped according to the WHO classification system. Cases were categorized as having PSOL or ocular lymphoma with suspected systemic involvement (SSI) based on submission forms and follow-up data. The majority of cases exhibited concurrent uveitis (75%) and secondary glaucoma (58%). Diffuse large B-cell lymphoma was the most common subtype (n = 86; 53%), followed by peripheral T-cell lymphoma (n = 44; 27%). Other subtypes included anaplastic large T- (n = 8; 5%) and B-cell (n = 4; 2.5%) lymphomas, and 15 cases (9%) were negative for all immunohistochemical markers. In sixty-nine cases (40%), adequate clinical data and sufficient survival data were obtained to distinguish PSOL from SSI. PSOL comprised the majority of cases (64%), while 36% had SSI. When covarying for age at diagnosis, the median survival time was significantly higher (P = 0.003) for cases of PSOL (154 days) versus those with SSI (69 days); hazards ratio of 0.47 for PSOL (95% CI: 0.241-0.937). The subtype of lymphoma did not affect survival time. Cats with PSOL represent a greater proportion of the disease population, and this subset of cats with intraocular lymphoma has a better clinical outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31328872/