Peer-reviewed veterinary case report
Lower airway disease linked to chronic mouth inflammation in cats
By Lorida, Olga et al.·Published in Frontiers in veterinary science·2025·Companion Animal Clinic·View original on PubMed →
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Original publication title: Clinical and histopathological investigation of the possible occurrence of tracheobronchial disease in cats with chronic gingivostomatitis.
- Species:
- cat
Plain-English summary
A group of 42 cats with chronic gingivostomatitis (FCGS), a painful oral condition, showed signs of respiratory problems during examinations. All the affected cats had secretions in their airways, and many had inflammation and swelling in their bronchial tissues. The study suggests that these respiratory issues could worsen the overall health of cats with FCGS and may contribute to the recurrence of their oral disease. It's important for veterinarians to check for and treat any respiratory problems in cats suffering from FCGS to improve their health outcomes.
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Abstract
INTRODUCTION: Feline chronic gingivostomatitis (FCGS) is a debilitating and highly painful inflammatory disorder of the feline oral cavity. Evidence suggests that feline chronic gingivostomatitis (FCGS) induces systemic effects that extend beyond localized oral pathology, contributing to overall health decline in affected cats. The aim of this study was to investigate the potential impact of FCGS on the lower respiratory tract. METHODS: This is a prospective study, that included 42 cats with clinical signs of FCGS and five healthy control cats exhibiting no signs of oral disease. All cats underwent physical, oral, and endoscopic examinations of the lower respiratory tract. Radiological evaluation of the thorax was also performed. Lesions in the respiratory tract detected upon endoscopy and the oral cavity were recorded and scored. In cats with FCGS biopsies from bronchial mucosa were obtained from sites showing endoscopic evidence of inflammation. RESULTS: Respiratory lesions were identified in all FCGS cats included in the study. Specifically, secretions were detected in 42 out of 42 (100%) cats, bronchial mucosal edema in 33 out of 42 (78.6%), a granular appearance in 14 out of 42 (33.3%), and hyperemia in 11 out of 42 (26.2%). Histopathological examination revealed mucosal and submucosal inflammation in 30 out of 36 (83.3%) cats and mucosal edema in 25 out of 36 (69.4%). Additionally, fibrosis was observed in 25 out of 36 (69.4%) samples, hyperplasia, or dilatation of bronchial glands in eight out of 36 (22.2%), and vascular wall thickening in 11 out of 36 (30.5%). Bronchial smooth muscle hypertrophy was present in 22 out of 36 (61.1%) examined samples. An attempt to correlate oral and respiratory lesion severity found no statistically significant correlation between stomatitis index, tracheobronchoscopy, or histopathological scores. DISCUSSION: FCGS appears to coexist with lower respiratory tract disease. During FCGS management, it might be essential to address any underlying respiratory disorder, as it may favor the outcome of the primary disease, while remaining unattended it may increase the likelihood of FCGS recurrence.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40642273/