Peer-reviewed veterinary case report
Short-term miltefosine and allopurinol treatment for dog
By Ayres, Eveline da Cruz Boa Sorte et al.·Published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria·2022·Hospital Veteriná·View original on PubMed →
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Original publication title: Clinical and parasitological impact of short-term treatment using miltefosine and allopurinol monotherapy or combination therapy in canine visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs with canine visceral leishmaniasis, a serious disease caused by parasites, were treated with either miltefosine, allopurinol, or a combination of both for 28 days. The treatment helped reduce the number of parasites in the skin and improved clinical signs of the disease, although antibody levels did not change significantly in that time. The combination of miltefosine and allopurinol was found to be more effective than using either medication alone. Overall, dogs showed improvement in their symptoms and a decrease in parasite load after treatment.
People also search for: dog leishmaniasis treatment · miltefosine for dogs · allopurinol for canine leishmaniasis
Abstract
Canine visceral leishmaniasis is an endemic zoonosis in Brazil. Dogs are the main hosts in urban environments. The treatment has gained popularity since the Brazilian government authorized miltefosine for canine treatment. The aim of this study was to investigate the clinical and parasitological impact of short-term treatment with miltefosine and allopurinol, alone and in combination. We evaluated the ability of pharmacotherapy to reduce clinical signs of disease, antibody levels using the indirect fluorescence antibody test (IFAT) and skin parasite load via qPCR after 28 days of treatment. The therapeutic protocols promoted a significant decline in clinical signs and in the skin parasite load in dogs (p < 0.01). We observed a moderate correlation between the skin parasite load and the clinical score in all three treatment groups (r > 0.5) Antibody levels did not decrease in this short period. It was concluded that the treatment with allopurinol reduced the number of parasites in the skin of dogs with visceral leishmaniasis in the short term. However, its efficiency is potentiated when associated with miltefosine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35920471/