Peer-reviewed veterinary case report
Feline intestinal large granular lymphocyte lymphoma signs
By Amaral, Camila Issa et al.·Published in Veterinary research communications·2025·Departamento de Clí, Brazil·View original on PubMed →
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Original publication title: Clinical and pathological characterization of a feline intestinal large granular lymphocyte lymphoma (LGLL).
- Species:
- cat
Plain-English summary
A five-year-old neutered male domestic cat was brought to the vet after experiencing three months of vomiting, not eating much, losing weight, and having abdominal pain. An ultrasound showed thickening of the intestine, which raised concerns about a possible tumor. The vet performed surgery to remove part of the intestine, and tests confirmed the presence of intestinal large granular lymphoma, a type of cancer. The cat's condition was diagnosed based on the appearance of the tumor cells. Treatment options would typically include chemotherapy, but the specific outcome for this cat isn't mentioned.
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Abstract
A five-year-old neutered male domestic cat presented with a three-month history of vomiting, hyporexia, progressive weight loss, and abdominal pain. Ultrasound revealed a significant increase in the thickness of the ileum, suggestive of a neoplastic process. Enterectomy and enteroanastomosis was performed, and the sample was sent for histopathological examination. Grossly, the intestine was tortuous and was irregular. In the antimesenteric portion, a 1.4 cm thick, annular, homogenous, white and soft mass was present slightly reducing luminal diameter. Histologically, the neoplastic cells were arranged in sheets of large and pleomorphic round cells with numerous intracytoplasmic eosinophilic granules extending from the lamina propria to the serosa. Tumor cell immunolabelling was for CD3, multifocal for granzyme B and absent for CD79a and CD20. Based on the morphology and immunophenotyping of the neoplastic cells, the diagnosis of intestinal large granular lymphoma was made.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40343496/