Peer-reviewed veterinary case report
Early signs of kidney injury in female dogs with pyometra infection
By Gasser, Beatriz et al.·Published in Scientific reports·2020·School of Agrarian Sciences and Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra.
Plain-English summary
A group of female dogs with a serious infection called pyometra were studied to find out how to spot early signs of kidney injury. Many of these dogs showed some kidney damage, but not all were classified as having sepsis based on standard tests. Researchers found that certain lab results and ultrasound measurements could help identify kidney injury more accurately. For example, high levels of protein in urine and low levels of certain blood components were strong indicators of kidney problems. Recognizing these signs early can help vets start treatment sooner, improving the chances of recovery.
People also search for: dog kidney injury symptoms · pyometra treatment in dogs · early signs of kidney disease in dogs
Abstract
The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variables in 20 bitches with pyometra as sepsis models and 12 healthy controls. All animals with pyometra presented some degree of renal damage on histological examination; however, sequential organ failure assessment (SOFA) classified only 40% cases with sepsis. AKI derived from systemic infection was identified in 57% of cases with hypoperfusion and in 22% with inflammation, being an affection of multifactorial origin. Among the evaluated parameters, urinary protein/creatinine ratio >0.15, serum albumin <2.94 mg/dL, time-averaged minimum velocity <21.5 cm/s, renal length/aorta diameter ratio >5.93, pulsatility index >1.53, haematocrit <45%, time-averaged maximum velocity <45.7 cm/s, haemoglobin <16 g/dL, leukocytes >12.53 × 10/uL, and cortical contrast peak intensity <69%, in the order of accuracy, are significant indicators of septic AKI with an accuracy >80%. Thus, AKI is a very prevalent condition in septic patients, derived mainly from changes in renal perfusion and inflammation. Additionally, reviewing the SOFA score parameters is suggested to identify renal failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32488080/