Peer-reviewed veterinary case report
Clinical and virological findings in pups naturally infected by canine parvovirus type 2 Glu-426 mutant.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2005
- Authors:
- Decaro, Nicola et al.
- Affiliation:
- Department of Animal Health and Well-being · Italy
- Species:
- dog
Plain-English summary
In a recent case involving two litters of puppies infected with a specific strain of canine parvovirus type 2, six pups were closely monitored for signs of illness and changes in their blood. Thankfully, the symptoms were mild; the puppies experienced mucoid diarrhea for about 3.5 days and showed signs of being very tired for about 1.5 days. Only two of the pups had a fever and ate less than usual. The virus was found in their feces for varying lengths of time, with the highest levels detected around day 10. Overall, the infection was mild, and the pups did not experience severe symptoms like vomiting or bloody diarrhea.
Abstract
An outbreak of canine parvovirus type 2 infection caused by the Glu-426 mutant in 2 litters of pups is reported. The infected pups (n = 6) were monitored daily for evidence of clinical signs and hematological changes and for the evaluation of viral shedding in the feces. The disease induced by the Glu-426 mutant was mild in all the infected pups. Vomiting and hemorrhagic diarrhea were not observed; however, the pups developed mucoid diarrhea (3.5 median days), depression (1.5 median days), and relative leukopenia and lymphopenia (2.5 median days). Fever and loss of appetite were observed only in 2 pups. Virus was detected in the feces for 4.5, 6.5, and 46 median days by hemagglutination, virus isolation on cell cultures, and real-time polymerase chain reaction (PCR), respectively. By real-time PCR, the highest viral DNA titers were detected in the feces of both litters at day 10, reaching median values of more than 10(10) DNA copies/mg of feces.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15825493/