Peer-reviewed veterinary case report
How well chemo sensitivity tests predict cancer treatment in dogs
By Henry, C J et al.·Published in Journal of the American Animal Hospital Association·2001·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Clinical assessment of a chemosensitivity assay as a treatment planning tool for dogs with cancer.
- Species:
- dog
Plain-English summary
A group of dogs with cancer underwent a special test to see how their tumors would respond to chemotherapy before starting treatment. They were given a combination of two chemotherapy drugs, mitoxantrone and cyclophosphamide, but the test results did not reliably predict how well the dogs would respond to the treatment or how long they would survive. In another part of the study, the test was used to guide therapy for dogs with lymphoma that did not respond to previous treatments, but again, the results did not show a clear connection to treatment success.
People also search for: dog cancer treatment options · lymphoma in dogs · chemotherapy response in dogs
Abstract
This study evaluated the clinical utility of a commercially available chemosensitivity assay. In the first part of the study, tumor tissues from dogs with various malignancies were tested, and the dogs were treated with a mitoxantrone/cyclophosphamide combination protocol. Tumor response was evaluated and compared to the predicted response. Assay results were not a significant predictor of clinical response to chemotherapy or of survival time. In the second part of the study, assay results were used to direct therapy in dogs with refractory lymphoma. There was no significant correlation (p equals 0.323) between predicted response and case outcome.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11300524/