Peer-reviewed veterinary case report
Single dose of immune plasma to treat parvovirus in dogs
By Bragg, Ryan F et al.·Published in Journal of the American Veterinary Medical Association·2012·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clinical evaluation of a single dose of immune plasma for treatment of canine parvovirus infection.
- Species:
- dog
Plain-English summary
A group of 14 dogs with parvovirus infection (CPV enteritis) were treated with a special immune plasma to see if it could help them recover faster. Unfortunately, the treatment did not show any benefits compared to a saline solution, as there were no significant differences in their blood cell counts, weight changes, or how long they stayed in the hospital. This means that the immune plasma did not improve their condition or speed up their recovery. Pet owners should be aware that this treatment may not be effective for dogs suffering from parvovirus.
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Abstract
OBJECTIVE: To evaluate the efficacy of administration of a single 12-mL dose of canine parvovirus (CPV)-immune plasma for treatment of CPV enteritis. DESIGN: Prospective, randomized, double-blinded, placebo-controlled clinical trial. ANIMALS: 14 dogs with naturally occurring CPV enteritis. PROCEDURES: Dogs were assigned to treatment groups on the basis of randomization tables and were administered a single i.v. dose of CPV-immune plasma (treatment group) or an equivalent volume of saline (0.9% NaCl) solution (placebo group) within 18 hours after admission to the hospital. Treatment and outcome variables evaluated included neutrophil, monocyte, and CPV counts; number of days of hospitalization; changes in body weight; and cost of treatment. RESULTS: When dogs treated with CPV-immune plasma were compared with dogs treated with saline solution, there were no significant differences detected among neutrophil or monocyte counts, magnitude of viremia, weight change, number of days of hospitalization, or cost of treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Administration of a single 12-mL dose of immune plasma soon after the onset of CPV enteritis in dogs was not effective in ameliorating clinical signs, reducing viremia, or hastening hematologic recovery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22380808/