Peer-reviewed veterinary case report
Signs and survival in cats with bladder cancer treated with meloxicam
By Bommer, Nicholas X et al.·Published in Journal of feline medicine and surgery·2012·Royal (Dick) School of Veterinary Studies, United Kingdom·View original on PubMed →
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Original publication title: Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam.
- Species:
- cat
Plain-English summary
An older cat, around 13 years old, was diagnosed with transitional cell carcinoma (a type of bladder cancer) after showing signs like blood in the urine and difficulty urinating. The cat was treated with meloxicam, a common anti-inflammatory medication, and most of the cats in the study showed improvement in their symptoms. On average, these cats lived for about 311 days after treatment, with some living much longer. The study also found that the presence of COX-2 in the tumors was linked to shorter survival times.
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Abstract
Records of 11 cats with transitional cell carcinoma of the urinary bladder, which had been treated with meloxicam, were reviewed for signalment, duration of clinical signs prior to diagnosis, results of diagnostic imaging, whether or not concurrent surgery was performed and survival. Immunohistochemical expression of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) was assessed in the tumours of seven cats. Tumour location varied greatly. The cats had a mean age of 13 years. Three cats had a previous diagnosis of feline idiopathic cystitis of up to 2008 days duration. Ten of the cats showed clinical improvement (reduction of haematuria and/or dysuria), with a mean survival time (MST) of 311 days (range 10-1064); 1-year survival of 50%. All seven bladders assessed for COX staining were COX-1 positive and five were COX-2 positive. The MST for the COX-2-positive cats was 123 days, the MST for the COX-2-negative cases was 375 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22408147/