Peer-reviewed veterinary case report
Stem cell treatment helps cats with chronic mouth inflammation not
By Valentine S Williams et al.·Published in Journal of Feline Medicine and Surgery·2025·Gallant, San Diego, CA, USA, GB·View original on DOAJ →
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Original publication title: Clinical field study evaluating the safety and efficacy of allogeneic uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis
- Species:
- cat
Plain-English summary
A group of 46 cats with severe gum disease (refractory feline chronic gingivostomatitis) received two doses of stem cells derived from the uterus to see if it could help their condition after tooth extractions. Many of the cats showed significant improvement in their quality of life and healing of oral lesions within two weeks of treatment, with continued benefits observed over the following months. The treatment was generally well tolerated, with only mild side effects noted. This study suggests that stem cell therapy could be a safe and effective option for cats suffering from this painful condition.
People also search for: cat gum disease treatment · feline chronic gingivostomatitis stem cell therapy · cat tooth extraction recovery
Abstract
Objectives The present study evaluated the safety and efficacy of intravenous, allogeneic uterine-derived mesenchymal stem cells (UMSCs) for client-owned cats with refractory feline chronic gingivostomatitis (FCGS). Methods This was a 90-day prospective, multi-site, baseline-controlled, clinical trial involving 46 cats with refractory FCGS after partial- or full-mouth extractions. Cats received two doses of 20 million UMSCs, 14 days apart. Effectiveness was evaluated at days 14, 28, 60 and 90 using owner-reported assessment of overall response (ORA), client-specific outcome measures (CSOM) of quality-of-life improvement and veterinarian-assessed global oral lesion score (GOLS) tissue healing. Safety assessments included clinical observations and clinical pathology. Results Treatment success rates at days 28, 60 and 90 were 61.4% (27/44), 76.3% (29/38) and 78.8% (26/33) for CSOM; 65.9% (29/44), 73.7% (28/38) and 75.8% (25/33) for ORA; and 31.8% (13/44), 47.5% (18/38) and 45.5% (15/33) for GOLS. CSOM and GOLS on day 14 after a single dose were 52.3% (23/44) and 25.0% (11/44), respectively. Cats treated within 6 months of tooth extraction had greater improvement in GOLS. There were no statistically significant differences in outcomes between cats with partial- or full-mouth extractions. Adverse events were generally mild and transient, with most related to underlying disease. All six serious adverse events were either unlikely to be due to, or in one case inconclusively attributed to, UMSC therapy. Conclusions and relevance Repeated intravenous UMSC therapy was well tolerated and demonstrated clinically meaningful improvement in quality of life in cats with refractory FCGS within 2 weeks of treatment. In addition, oral lesions continued to improve over time. These results support the safe and effective use of UMSCs for this life-threatening condition.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1177/1098612X251385852