Peer-reviewed veterinary case report
Cat mammary gland swelling after one shot of contraceptive injection
By Loretti, Alexandre Paulino et al.·Published in Journal of Feline Medicine and Surgery·2005·Section of Veterinary Pathology, Department of Veterinary Clinical Pathology, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, Brazil·View original on Crossref →
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Original publication title: Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate
- Species:
- cat
Plain-English summary
Eight young female cats developed swelling in their mammary glands after receiving a single injection of a contraceptive hormone called depot medroxyprogesterone acetate (MPA). This condition, known as feline mammary fibroepithelial hyperplasia (FMFH), was linked to the hormone's effects, which remained high even after the cats were neutered. Tests showed that the hormone was still active in their bodies, leading to changes in the mammary tissue. The cats were treated, and while the abstract does not specify the outcome, it suggests that careful monitoring of hormone treatments is important to prevent such reactions.
People also search for: cat mammary gland swelling · feline fibroepithelial hyperplasia treatment · depot medroxyprogesterone acetate side effects
Abstract
Feline mammary fibroepithelial hyperplasia (FMFH) following a single injection of depot medroxyprogesterone acetate (MPA) was observed in eight intact young queens. The repository compound is marketed as a veterinary product by a local pharmaceutical company with an indication for contraception in cats. The drug was administered according to the recommended doses and injection frequencies. Serum hormone assays performed immediately before neutering and 3 weeks after neutering detected persistently high levels of progesterone suggesting that depot MPA was still exerting its influence. No corpora lutea were found in those cases ruling out ovaries as the main site of progesterone. Immunohistochemistry performed on the hyperplastic mammary glands detected progesterone receptors in the nuclei of ductal cells, and growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the cytoplasm of ductal epithelium. Overdosing should be considered here as the animals received at least 10 mg/kg of depot MPA in a single injection. Progestin-induced local synthesis of GH and IGF-I in mammary epithelial cells is suggested as one of the pathogenic mechanisms involved in the development of FMFH.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2004.05.002