Peer-reviewed veterinary case report
Dog with skin lymphoma nodules goes into remission after verdinexor
By Grady, Jennifer Lynn et al.·Published in Journal of the American Animal Hospital Association·2024·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Clinical Remission of Cutaneous Lymphoma in a Dog Treated with Verdinexor.
- Species:
- dog
Plain-English summary
A 5-year-old female spayed pit bull mix was brought to the vet after developing multiple skin lumps over two weeks, along with weight loss and tiredness. After tests, she was diagnosed with cutaneous epitheliotropic T-cell lymphoma, a type of skin cancer. The vet started her on a medication called verdinexor, given twice a week. Remarkably, just one week into treatment, the skin lumps completely disappeared, and she has stayed healthy and cancer-free for 17 months since starting the medication.
People also search for: dog skin lumps treatment · pit bull lymphoma symptoms · verdinexor for dog cancer
Abstract
A 5 yr old female spayed pit bull terrier mix was evaluated for development of multiple dermal nodules over the previous 2 wk with concurrent weight loss and lethargy. A definitive diagnosis of cutaneous epitheliotropic T-cell lymphoma was obtained through histopathology and immunohistochemistry. Treatment was initiated with 32.9 mg/m2 (1.2 mg/kg) of oral verdinexor twice per week, according to label guidance. One week after treatment initiation, clinical remission was noted with complete resolution of the cutaneous nodules. The dog has continued twice-weekly treatments without any interruption and remains in complete remission 17 mo following initiation of verdinexor therapy. This case provides evidence for the utility of verdinexor in the treatment of canine cutaneous epitheliotropic T-cell lymphoma.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39235783/