Peer-reviewed veterinary case report
Treatment of dog skin leishmaniasis with furazolidone and domperidone
By Passos, Stela Rechinelli et al.·Published in International journal of antimicrobial agents·2014·Laborató, Brazil·View original on PubMed →
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Original publication title: Clinical treatment of cutaneous leishmaniasis in dogs with furazolidone and domperidone.
- Species:
- dog
Plain-English summary
A group of dogs with skin lesions caused by cutaneous leishmaniasis (a disease caused by a parasite) were treated with a combination of furazolidone and domperidone. After 21 days of treatment, seven out of eight dogs showed significant healing of their skin lesions and did not have any recurrences over the next year. Although some tests still detected the parasite during healing, the dogs improved clinically. This treatment appears to be effective for helping dogs recover from this condition.
People also search for: dog skin lesions treatment · cutaneous leishmaniasis in dogs · furazolidone for dogs · dog parasite infection treatment
Abstract
Cutaneous leishmaniasis (CL) is a zoonosis and a public health problem in countries of subtropical America. The aim of this study was to investigate the efficacy of furazolidone and domperidone treatment of dogs naturally infected with Leishmania (Viannia) braziliensis. Infection was confirmed by PCR and parasite culture of tissue collected from skin scrapings of the lesion borders of dogs. Naturally infected animals were divided into control (n=4) and treatment (n=8) groups. The treatment group was administered furazolidone for 21 days interspersed with domperidone for 10 days by oral gavage. Dogs that showed no lesion healing during this period were administered the same treatment cycle for up to 93 days. Among the eight treated animals, seven were clinically cured without recurrence of skin lesions during the 12-month study period. However, during lesion healing, skin scrapings were positive for L. (V.) braziliensis by PCR; no growth of the protozoan in NNN-LIT medium occurred until the end of follow-up. These results suggest that treatment with furazolidone and domperidone is effective for epithelialisation and lesion healing of dogs with clinical CL caused by L. (V.) braziliensis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25219877/