Peer-reviewed veterinary case report
Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology.
- Journal:
- The Veterinary record
- Year:
- 2018
- Authors:
- Favril, Sophie et al.
- Affiliation:
- Small Animal Department
Plain-English summary
Surgical treatment of cancer in pets can be challenging because it's often hard for surgeons to tell the difference between cancerous tissue and healthy tissue during surgery. Currently, they mainly rely on looking and feeling for tumors, which can lead to cancer coming back in some cases. A new technique called near-infrared (NIR) fluorescence imaging uses a special dye that lights up cancer cells when exposed to a specific light, helping surgeons see what they need to remove more clearly. This method is safe, affordable, and easy to use, and it could also help identify important lymph nodes during surgery. The article discusses how this imaging technique is being studied in people and suggests it could be very useful for treating pets with cancer as well.
Abstract
One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost-effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29705740/