Peer-reviewed veterinary case report
Seizures and rapid decline from brain tumors in 2 dogs
By Rossmeisl, J H et al.·Published in Journal of veterinary internal medicine·2012·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clinicopathologic features of intracranial central neurocytomas in 2 dogs.
- Species:
- dog
Plain-English summary
Two dogs experienced seizures and rapid neurological decline due to rare brain tumors called central neurocytomas, which are typically found in humans. Within just five days of showing symptoms, both dogs sadly passed away from complications related to the tumors. One dog underwent a brain MRI that showed abnormal masses in the lateral ventricles of the brain, and further tests confirmed the tumors' neuronal characteristics. This case highlights the importance of considering central neurocytomas as a potential diagnosis for dogs with similar brain mass symptoms.
People also search for: dog seizures · brain tumor in dogs · central neurocytoma in dogs · dog neurological decline · dog MRI brain results
Abstract
BACKGROUND: In humans, central neurocytomas are rare and typically benign intracranial tumors found within the lateral ventricles, although extraventricular variants have been reported. Intracranial central neurocytomas have not been previously recognized in domestic animals. OBJECTIVES: To describe the clinicopathologic features of canine intracranial central neurocytomas. ANIMALS: Two dogs with spontaneous intracranial and intraventricular neoplasms. RESULTS: Both dogs experienced seizures, rapid neurological deterioration, and death from tumor-associated complications within 5 days of the onset of clinical signs, and had neoplastic masses within the lateral ventricles. A brain MRI was performed in 1 dog, which revealed a T1-isointense, heterogeneously T2 and FLAIR hyperintense, and markedly and heterogeneously contrast-enhancing mass lesions within both lateral ventricles. Histologically, the neoplasms resembled oligodendrogliomas. The diagnosis of central neurocytoma was supported by documenting expression of multiple neuronal markers, including neuron-specific enolase, synaptophysin, neural-cell adhesion molecule, and neuronal nuclear antigen within the tumors, and ultrastructural evidence of neuronal differentiation of neoplastic cells. CONCLUSIONS AND CLINICAL IMPORTANCE: Central neurocytoma should be a differential diagnosis for dogs with intraventricular brain masses. Morphologic differentiation of central neurocytoma from other intraventricular neoplasms, such as ependymoma or oligdendroglioma, can be difficult, and definitive diagnosis often requires immunohistochemical or ultrastructural confirmation of the neural origin of the neoplasm.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22233345/