Peer-reviewed veterinary case report
Tongue masses in dogs linked to T-zone lymphoma diagnosis
By Harris, L J et al.·Published in Veterinary and comparative oncology·2018·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Clinicopathologic features of lingual canine T-zone lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with tongue masses were diagnosed with a type of cancer called T-zone lymphoma (TZL), which is known for its slow-growing nature. Most of these dogs also had swollen lymph nodes or increased white blood cells. After treatment, seven dogs went into remission, while four had stable disease, showing that this type of lymphoma can sometimes be managed effectively. However, one dog did not respond to treatment and had a more aggressive form of the disease. This case highlights the importance of recognizing TZL as a potential cause of tongue tumors in dogs.
People also search for: dog tongue tumor treatment · canine T-zone lymphoma symptoms · swollen lymph nodes in dogs
Abstract
Canine T-zone lymphoma (TZL) is a subtype of T-cell lymphoma characterized by unique histologic pattern and cytomorphology, immunophenotypic loss of CD45 expression, and an indolent clinical behaviour. Dogs with TZL typically present with 1 or more enlarged lymph nodes and/or lymphocytosis. We describe a novel extranodal presentation of TZL involving the tongue. Twelve dogs with tongue masses were diagnosed with lingual TZL based on a variable combination of immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry and/or PCR for antigen receptor rearrangement (PARR) assay. Eleven dogs exhibited concurrent lymphocytosis and/or lymph node enlargement. Three cases were initially diagnosed as plasma cell tumours based on histology alone, thereby revealing a potential diagnostic challenge. Seven dogs achieved clinical remission and 4 achieved stable disease following variable treatment, consistent with the indolent nature of typical TZL involving the lymph nodes and peripheral blood. In 1 case the TZL resulted in progressive disease and failure to respond to treatment. In this case, the TZL exhibited histologic features of a higher grade neoplasm. This case series highlights a unique presentation of TZL and identifies a new differential diagnosis for lingual neoplasia. In this study, we characterize the clinical presentation, diagnostic features and patient outcomes of 12 dogs with lingual TZL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28752538/