Peer-reviewed veterinary case report
What Pgp and p53 mean for canine lymphoma grades and treatment
By Dhaliwal, Ravinder S. et al.·Published in Journal of the American Animal Hospital Association·2013·View original on Crossref →
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Original publication title: Clinicopathologic Significance of Histologic Grade, Pgp, and P53 Expression in Canine Lymphoma
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer) were studied to see how certain proteins (P-glycoprotein and p53) affected their treatment outcomes. All 31 dogs received a combination chemotherapy protocol after being diagnosed. While most dogs showed high levels of P-glycoprotein, the presence of p53 was linked to longer survival times. On average, the dogs lived for about 246 days after treatment, with a remission period lasting around 137 days. This suggests that monitoring p53 levels could help predict how well a dog might respond to treatment.
People also search for: dog lymphoma treatment · canine cancer survival rates · p53 protein in dogs
Abstract
To characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades of canine multicentric lymphosarcoma (LSA), 31 cases of LSA without prior treatment were studied. The expression levels of the Pgp and p53 proteins were evaluated for their clinicopathologic significance among standard histologic evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples of 31 previously untreated LSA cases to detect the expression of Pgp and p53. All dogs were subsequently treated with a combination chemotherapy protocol. Remission and survival durations were evaluated for correlation with histologic grade and presence of drug resistance markers. Of the 31 cases, 24 (80%) and 7 (22%) were positive for Pgp and p53, respectively. Overall, the median survival and duration of remission in the study was 246 days and 137 days, respectively. The National Cancer Institute working formulation histologic grade was not associated with either survival or duration of first remission (DOR). The Pgp protein expression and DOR and survival was not statistically significant. Expression of p53 was statistically correlated with survival.
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Search related cases →Original publication on Crossref: https://doi.org/10.5326/jaaha-ms-5843