Peer-reviewed veterinary case report
What P-glycoprotein and p53 mean for dog lymphoma grades and treatment
By Dhaliwal, Ravinder S et al.·Published in Journal of the American Animal Hospital Association·2013·Michigan State University, United States·View original on PubMed →
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Original publication title: Clinicopathologic significance of histologic grade, pgp, and p53 expression in canine lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with multicentric lymphoma (a type of cancer) were treated with a combination of chemotherapy. Researchers looked at the levels of two proteins, P-glycoprotein (Pgp) and p53, to see if they could predict how well the dogs would respond to treatment. While most dogs showed some level of Pgp expression, only a few had p53. The study found that dogs with higher p53 levels tended to live longer after treatment, with an average survival of about 246 days.
People also search for: dog lymphoma treatment · canine cancer survival rates · p53 protein in dogs · chemotherapy for dog lymphoma
Abstract
To characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades of canine multicentric lymphosarcoma (LSA), 31 cases of LSA without prior treatment were studied. The expression levels of the Pgp and p53 proteins were evaluated for their clinicopathologic significance among standard histologic evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples of 31 previously untreated LSA cases to detect the expression of Pgp and p53. All dogs were subsequently treated with a combination chemotherapy protocol. Remission and survival durations were evaluated for correlation with histologic grade and presence of drug resistance markers. Of the 31 cases, 24 (80%) and 7 (22%) were positive for Pgp and p53, respectively. Overall, the median survival and duration of remission in the study was 246 days and 137 days, respectively. The National Cancer Institute working formulation histologic grade was not associated with either survival or duration of first remission (DOR). The Pgp protein expression and DOR and survival was not statistically significant. Expression of p53 was statistically correlated with survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23535752/