Peer-reviewed veterinary case report
Factors linked to high CO2 in cats admitted with kidney disease
By Donati, P A et al.·Published in New Zealand veterinary journal·2021·UCICOOP·View original on PubMed →
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Original publication title: Clinicopathological factors associated with the presence of hypercapnia at admission in hospitalised cats with decompensated chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of 39 cats with advanced kidney disease was evaluated for breathing issues upon admission to a veterinary hospital. About 28% of these cats had high levels of carbon dioxide in their blood, which can indicate serious health problems. The study found that higher blood creatinine and sodium levels were linked to this condition. While the cats received treatment, the length of their hospital stay did not differ significantly based on whether they had high carbon dioxide levels. Monitoring blood gases and electrolytes is important for managing cats with chronic kidney disease.
People also search for: cat kidney disease symptoms · cat breathing problems · high creatinine levels in cats · chronic kidney disease treatment for cats
Abstract
AIMS: To evaluate associations between clinicopathological variables and hypercapnia measured in cats with decompensated chronic kidney disease (CKD) on admission to a veterinary hospital. METHODS: This is a retrospective, cross-sectional study of cats (n = 39) that presented to a tertiary veterinary hospital in Argentina between June 2015 and December 2017 with blood creatinine concentrations >140 μmol/L, and abdominal ultrasound results consistent with CKD. Data recorded included venous partial pressure of CO(PvCO), blood pH, haematocrit and concentrations of glucose, potassium, sodium, corrected sodium (Na), and ionised calcium in blood. A logistic regression model was used to assess associations between the presence of hypercapnia (PvCO ≥ 44.7 mmHg) and the other clinicopathologic variables. The duration of hospitalisation was compared in cats with and without hypercapnia using the Wilcoxon Rank Sum test. RESULTS: The final study population comprised 39 cats. Eleven cats (28.2%) had hypercapnia. In the logistic regression model, two independent variables were associated with the presence of hypercapnia at admission in cats with CKD: the concentration of creatinine in blood (OR = 1.06 (95% CI = 1.016-1.108); p = 0.007) and Na(OR = 1.33 (95% CI = 1.08-1.63); p = 0.005). There were no statistically significant differences in the length of hospital stay between the two groups. CONCLUSIONS AND CLINICAL RELEVANCE: There appears to be an association between elevated concentrations of creatinine and Nain blood, and hypercapnia in cats with CKD, suggesting careful assessment of blood gas and electrolyte parameters during hospitalisation is required. Further prospective studies are needed to evaluate the mechanisms behind this association and the association of hypercapnia with disease outcome including mortality.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34085906/