Peer-reviewed veterinary case report
Skin sores and kidney damage in 178 dogs with CRGV
By Walker, Joshua James Allen et al.·Published in The Veterinary record·2021·Anderson Moores Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: Clinicopathological features of cutaneous and renal glomerular vasculopathy in 178 dogs.
- Species:
- dog
Plain-English summary
A group of 178 dogs with skin lesions and potential kidney problems were studied to understand a serious condition called cutaneous and renal glomerular vasculopathy (CRGV). Many of these dogs showed symptoms like skin lesions on their limbs, and some developed acute kidney injury (AKI) within a few days of the lesions appearing. Notably, neurological signs were observed in some dogs, and a significant number had low platelet counts. The study highlighted that the risk of kidney injury can develop over a longer period than previously thought, and early signs can vary.
People also search for: dog skin lesions and kidney problems · CRGV in dogs · dog acute kidney injury symptoms · dog neurological signs with skin issues
Abstract
BACKGROUND: One hundred seventy-eight dogs with cutaneous and renal glomerular vasculopathy (CRGV) were evaluated to further the understanding of the natural course of CRGV. CRGV, a form of thrombotic microangiopathy, can cause skin lesions and potentially acute kidney injury (AKI) with a high mortality rate. METHODS: Cases were submitted from multiple practices from 2012 until June 2019. Clinical histories and laboratory data were reviewed to describe the features of CRGV. RESULTS: Most cases (91%) occurred between November and May. Fifteen dogs (8.4%) with CRGV were in contact with another dog that developed skin lesions +/- AKI. Limb lesions were present on 144 dogs (80.9%) at presentation. Median time from appearance of a lesion to AKI was 3 days (range -4-45 days). Neurological signs occurred in 33 dogs (18.6%) including at presentation in 2 (1.1%). Systemic signs were present in 13 dogs prior to a skin lesion (7.3%). Non-steroidal anti-inflammatory drugs were prescribed prior to AKI identification in 92 of 170 dogs (54.1%). Thrombocytopenia was present in 115 of 137 (83.9%) of dogs. CONCLUSION: The timeframe over which AKI may develop is longer than previously reported, neurological signs can be identified at presentation or during hospitalisation, and thrombocytopenia is even more common than previously reported.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33829498/