Peer-reviewed veterinary case report
Canine transmissible venereal tumour in dogs with leishmaniasis study
By Marino, G et al.·Published in The Journal of small animal practice·2012·Department of Veterinary Public Health, Italy·View original on PubMed →
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Original publication title: Clinicopathological study of canine transmissible venereal tumour in leishmaniotic dogs.
- Species:
- dog
Plain-English summary
A group of dogs with canine transmissible venereal tumor (a type of tumor that can spread through sexual contact) and leishmaniasis (a disease caused by parasites) was studied to understand how these two conditions affect each other. The tumors in these dogs were often large and aggressive, and there were no signs that they would shrink on their own. In some cases, the tumors contained Leishmania parasites, which may have been carried by immune cells. This suggests that the leishmaniasis could weaken the dog's ability to fight off the tumor.
People also search for: dog tumor treatment · canine transmissible venereal tumor symptoms · leishmaniasis in dogs treatment
Abstract
INTRODUCTION: Canine transmissible venereal tumour is occasionally observed in leishmaniotic dogs, and Leishmania amastigotes can be harboured in canine transmissible venereal tumour cells. OBJECTIVES: The aim of this paper was to investigate the clinicopathological significance of the association of both diseases. METHODS: Nineteen dogs affected by canine transmissible venereal tumour and canine leishmaniasis were studied retrospectively. RESULTS: In these dogs, the tumour manifested a large size and often aggressive behaviour (42%) and no predictive sign of spontaneous regression was observed. Sporadic Leishmania amastigotes were found within the canine transmissible venereal tumour in three cases, probably transported by infected macrophages often infiltrating the tumour. A high Leishmania parasitisation of canine transmissible venereal tumour was observed in two other cases and verified by immunohistochemistry. CLINICAL SIGNIFICANCE: Canine transmissible venereal tumour is a tumour of the dog able to harbour a large number of Leishmania parasites. Alternatively, the systemic disease (canine leishmaniasis) may lower the immune defence against malignancy (canine transmissible venereal tumour).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22489831/