Peer-reviewed veterinary case report
How clotrimazole and enilconazole reach dog sinuses in fungal nose
By Sharman, M et al.·Published in The Journal of small animal practice·2012·Department of Veterinary Clinical Sciences, Australia·View original on PubMed →
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Original publication title: Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis.
- Species:
- dog
Plain-English summary
Nine dogs with a fungal infection in their sinuses were treated with either clotrimazole or enilconazole, two antifungal medications. The treatments were delivered directly into the sinuses through a small opening created by the veterinarian. While the antifungal agents reached various parts of the nasal cavity, they did not stay in those areas very well. This means that while the method can work, the effectiveness may vary, and more treatments might be needed to fully clear the infection.
People also search for: dog nasal infection treatment · clotrimazole for dogs · enilconazole sinus infection dog
Abstract
OBJECTIVES: Multiple topical treatments are often required for clinical cure of mycotic rhinosinusitis in dogs. The objective of this study was to describe the distribution and retention of enilconazole and clotrimazole solutions using a temporary trephination protocol. METHODS: Nine client-owned dogs diagnosed with mycotic rhinosinusitis between March 2008 and December 2009 were prospectively enrolled and were sequentially allocated to receive treatment with either clotrimazole (1% in polyethylene glycol) or enilconazole (10% solution), after imaging and rhinoscopic assessment. Both frontal sinuses were trephined, debrided and flushed with saline. Infusion was administered via frontal sinuses with dogs in sternal recumbency and computed tomography (CT) performed 5 minutes after completion. Distribution was scored 1 to 4 at the canine tooth, premolar 4, cribriform plate and frontal sinus on both sides, for a maximum score of 32. RESULTS: Distribution of antifungal agents to all regions of the nasal cavity and frontal sinuses was achievable, but varied considerably. Retention was poor in 10 of 18 regions assessed. CLINICAL SIGNIFICANCE: Distribution of antifungal agents within the frontal sinuses is achievable using temporary trephination; however, distribution is variable and retention is often poor.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22300493/