Peer-reviewed veterinary case report
Dog with clozapine poisoning showing drooling and fast heartbeat
By Fransson, Boel A et al.·Published in Journal of the American Animal Hospital Association·2002·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clozapine intoxication in a dog.
- Species:
- dog
Plain-English summary
A dog was brought in showing signs of excitement, excessive drooling, rapid heart rate, and high body temperature after suspected clozapine (a medication for human schizophrenia) exposure. Blood tests confirmed high levels of the drug in its system. The veterinarian treated the dog with activated charcoal to help absorb the toxin and provided supportive care. Fortunately, the dog recovered well after treatment.
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Abstract
Intoxication with clozapine in a dog, suspected from history and clinical signs at presentation, was confirmed by demonstration of decreasing serum levels of this drug. Clozapine is a tricyclic dibenzodiazepine used for treatment of human schizophrenia, and clinical signs of intoxication in humans include tachycardia, seizures, muscle fasciculations, agitation, and sialorrhea. This dog showed ptyalism, hyperthermia, tachycardia, and was easily excited by tactile or auditory stimulation. The calculated peak concentration of clozapine in this dog was approximately 6,000 ng/mL, and the elimination half-life (t(1/2)) was 5 hours. Charcoal administration and supportive care led to a successful outcome in this patient.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12220025/