Peer-reviewed veterinary case report
Dog developed deafness and kidney failure after gentamicin injection
By Fisk, Amanda et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2019·Emergency and Critical Care Department (Londoñ, United States·View original on PubMed →
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Original publication title: Cochleotoxicity and acute kidney injury secondary to parenteral gentamicin administration in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old neutered male Labrador retriever was brought in for severe kidney problems and was not urinating, likely caused by the antibiotic gentamicin. The vet initially treated the kidney injury with a high dose of furosemide, but this may have worsened the dog's condition. During his stay, the dog also lost his hearing due to damage from the medication. After 33 days of treatment, he was discharged, but unfortunately, he remained deaf.
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Abstract
A 5-year-old neutered male Labrador retriever dog was presented on referral for anuric acute kidney injury (AKI) presumed secondary to parenteral gentamicin administration. Initial management of AKI included a high dose of furosemide for 16 hours which may have contributed to the renal and cochlear damage. The dog received a total of 8 intermittent hemodialysis sessions during hospitalization. While in hospital, the dog became deaf, and brainstem auditory evoked response testing revealed absence of waveforms in both ears, consistent with bilateral deafness due to severe cochleotoxicity. After 33 days of hospitalization, the dog was discharged with persistent deafness, confirmed by a second brainstem auditory evoked response.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31523085/