Peer-reviewed veterinary case report
Dog with kidney disease causing severe protein loss and fibronectin
By Kamiie, J et al.·Published in Veterinary pathology·2009·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Collagenofibrotic glomerulonephropathy with fibronectin deposition in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old Shiba Inu was brought to the vet because he had severe protein in his urine, which can indicate kidney problems. Tests showed that his kidneys had abnormal deposits that were causing damage, leading to the proteinuria. This condition, known as collagenofibrotic glomerulonephropathy, is similar to a kidney issue seen in humans. Unfortunately, the abstract does not provide information on the treatment or outcome for this dog.
People also search for: dog protein in urine · Shiba Inu kidney disease · dog kidney problem symptoms
Abstract
We report herein a case of collagenofibrotic glomerulonephropathy in a 3-year-old Shiba Inu with severe proteinuria. Histologically, renal glomeruli were enlarged with massive deposition of a homogeneous eosinophilic substance within the mesangium and capillary walls. The deposits reacted weakly with periodic acid-Schiff, stained deep blue with Masson's trichrome, and were positive by immunofluorescence for type III collagen and fibronectin. Ultrastructurally, the deposits consisted of fibrils and amorphous material in the mesangial matrix and beneath the glomerular capillary endothelium. The fibrils had transverse bands analogous to those of collagen fibrils. Electron microscopy also revealed focal detachment of podocytes and foot process effacement in glomerular tufts, which suggested that podocyte injury had contributed to the development of proteinuria in this dog. The current case resembles collagenofibrotic glomerulonephropathy (CFGN) in humans in histopathologic, immunofluorescence, and electron microscopic findings. This is the first report of CFGN in a nonhuman species with glomerular deposition of fibronectin and type III collagen.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19276051/