Peer-reviewed veterinary case report
Dog with colorectal fungal infection caused by Basidiobolus
By Marclay, Margaux et al.·Published in Journal of veterinary internal medicine·2020·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Colorectal basidiobolomycosis in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old male French Bulldog was brought in for ongoing issues with his large intestine, including symptoms like diarrhea. The vet found a mass in the colon and thickening of the rectal lining, which led to a diagnosis of a fungal infection called basidiobolomycosis. After treatment with antifungal medications and prednisone, the dog's symptoms improved significantly within six weeks. Unfortunately, 15 weeks later, the dog collapsed and was euthanized, revealing a different underlying cancer at necropsy, but the initial fungal infection had resolved.
People also search for: dog diarrhea treatment · French Bulldog intestinal problems · basidiobolomycosis in dogs · dog cancer symptoms · antifungal treatment for dogs
Abstract
A 7-year-old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5-20 μm), irregularly shaped, pauciseptate hyphae that were Gomori methenamine silver and periodic acid-Schiff positive. Amplification and sequencing of ribosomal DNA extracted from paraffin-embedded tissues yielded a sequence with 97% identity to GenBank sequences for Basidiobolus ranarum. After itraconazole, terbinafine, and prednisone administration, clinical signs resolved rapidly, and sonographic lesions were largely absent after 6 weeks. Treatment was discontinued by the owner 15 weeks after diagnosis. Three weeks later, the dog collapsed acutely and was euthanized. Necropsy identified metastatic islet cell carcinoma and grossly unremarkable colorectal tissues. However, histopathology of the rectum disclosed multifocal submucosal granulomas with intralesional hyphae morphologically similar to those previously observed. This report is the first to describe medical treatment of gastrointestinal basidiobolomycosis in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32681715/