Peer-reviewed veterinary case report
Chemotherapy results and side effects in 23 cats with lymphoma
By Simon, D et al.·Published in Journal of veterinary internal medicine·2008·Department of Small Animal Medicine and Surgery, Germany·View original on PubMed →
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Original publication title: Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats.
- Species:
- cat
Plain-English summary
A group of 23 cats diagnosed with lymphoma received a combination of chemotherapy drugs to treat their cancer. About 74% of the cats went into complete remission, with the average duration of remission lasting around 264 days. The treatment was generally well-tolerated, with only mild side effects reported. Overall, the chemotherapy showed promising results, helping many cats live longer and healthier lives after treatment.
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Abstract
BACKGROUND: Different chemotherapy regimes have been described for feline lymphoma with varying outcomes. HYPOTHESIS: In cats with lymphoma, a long-term, multiagent chemotherapy protocol will be effective and carry acceptable toxicity. ANIMALS: Twenty-three cats with histologically or cytologically confirmed diagnosis of lymphoma. METHODS: Prospective, single-arm clinical trial in which cats were treated with a chemotherapy protocol consisting of a cyclic combination of l-asparaginase, vincristine, cyclophosphamide, doxorubicin, methotrexate, and prednisolone with a planned total treatment time of 122 weeks. RESULTS: Complete remission (CR) rate was 74% (n = 17). Fourteen percent of cats attained partial remission (PR). Median duration of first CR was 264 days (range, 45-2,485 days). Six-month, 1-, and 2-5-year remission rates were 75, 50, and 34%, respectively. Duration of PR ranged between 23 and 63 days. Median survival in cats with CR was 296 days (range, 50-2,520 days). Six-month, 1-, 2-, and 3-5-year survival rates in cats with CR were 82, 47, 34, and 27%, respectively. Survival of cats achieving PR ranged between 38 and 120 days. Of the analyzed variables, only anatomical location had a significant influence on remission duration (P=.022). Actual median treatment time in cats with CR was 128 days (18 weeks). Hematologic and gastrointestinal toxicosis was infrequent and mostly low grade. CONCLUSIONS AND CLINICAL IMPORTANCE: In this population of cats with lymphoma, chemotherapy was effective. With infrequent and mostly low-grade toxicosis, tolerability of the protocol may be considered good.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18312554/